A horrendous own-goal by Tottenham's Steed Malbranque put the club behind in the opening three minutes, and Frederic Kanoute doubled the lead just five minutes later. Tottenham rallied in the second half to pull level, as Jermain Defoe and Aaron Lennon scored two minutes apart, but Spurs would get no more and their comeback effort fell short.

Despite a 2-1 lead on aggregate, Sevilla came out looking like the more desperate team, and they took the game to Tottenham in the opening minutes. Christian Poulsen got free for a header inside the box in the third minute and headed a corner kick past keeper Paul Robinson. Malbranque was positioned on the post, and looked as though he would clear the ball off the line. However, the midfielder made a mess of the clearance, slicing the ball off of the outside of his foot and into his own net.

The home side would never recover from that terrible error, and went down two goals just five minutes later. Kanoute took possession from a throw in and worked a nice one-two with Alexander Kerzhakov inside the penalty area. The former Tottenham striker then took the return pass and maneuvered past Robinson for a neat finish and a 2-0 Sevilla advantage.

The goal gave the Spanish side a 4-1 lead on aggregate, and left Tottenham needing four goals to advance. Spurs tried to put a dent in their deficit in the final five minutes of the half, as they were able to control the play but came away empty.

Dimitar Berbatov got a good look at goal in the 41st minute when Didier Zokora made a run through the midfield and dropped the ball off for him. Unfortunately, the Bulgarian striker's shot went inches wide of the far post.

Berbatov had another chance before the halftime whistle, but was denied by the post. He brought down a bouncing ball inside the box and made a nice turn with it before drilling a low shot towards the left post. The shot had keeper David Cobeno beaten, but it came back off the post and Tottenham was still without a goal.

The play was better from Tottenham in the second half, and Spurs sprung to life in the 66th minute. Jermaine Jenas lobbed a free-kick into the box and Robbie Keane was able to get a hold of it and throw a shot towards goal. Defoe was positioned at the top of the six-yard box and turned the shot into the back of the net just seconds after coming on as a substitute, giving Tottenham life.

The hosts then leveled the match just one minute later, with Berbatov providing a cross from the right wing that produced a dangerous loose ball inside the box. Lennon was the first one to pounce on it and he arrived just in time to poke the ball past Cobeno and inside the right post.

Tottenham still needed two goals to go through, but Sevilla was able to keep them off the board the rest of the way, despite a few close calls.

Berbatov got free for a shot from the edge of the area that took a slight deflection off of a Sevilla defender and narrowly missed the upper-right corner. One minute later, Michael Dawson had a great chance at a volley eight yards from goal, but he didn't catch it clean and the shot dribbled wide.

Sevilla will now move on to face fellow Spanish side Osasuna, who downed Bayer Leverkusen 1-0 on Thursday for an easy 4-0 win on aggregate.

In other action on Thursday, Espanyol made it three La Liga clubs in the semifinals as they held Benfica to a 0-0 draw, moving on with a 3-2 aggregate score. They will take on the only non-Spanish side left in the competition, German club Werder Bremen, who secured a 4-1 win over AZ Alkmaar thanks to a pair of goals from Miroslav Klose.