Burnley defeated Manchester United 1-0 at Turf Moor, while Liverpool, Tottenham and Birmingham all recorded Premier League victories.
Brian Jensen saved a penalty as Burnley repelled the threat of the champions to record a shock win on their first home game in the top flight since 1976.
Robbie Blake had put the hosts in front with a superb near-post volley, only to upend Patrice Evra at the other end just before the break.
Michael Carrick took responsibility ahead of Michael Owen. But Jensen denied him, making a fine stop to allow Burnley to celebrate an amazing night.
Jermain Defoe grabbed a hat-trick as Tottenham went top of the Barclays Premier League with a 5-1 win at Hull.
Defoe and Wilson Palacios struck in the opening 14 minutes as Spurs raced out of the blocks at the KC Stadium.
Stephen Hunt gave Hull hope when his cross from a free-kick bounced in but Defoe scored again on the stroke of half-time and made sure in the last minute after a Robbie Keane header.
Liverpool got their season up and running with a convincing 4-0 victory over Stoke at Anfield.
Steven Gerrard created the first goal of the season for Fernando Torres, the Spaniard drilling home from 12-yards early on.
Glen Johnson, on his home debut, hooked in the second a minute from the break, Dirk Kuyt stabbed home the third from a Gerrard pass after 78 minutes, with David Ngog heading the fourth in injury-time.
James McFadden scored an injury-time penalty to earn Birmingham a dramatic 1-0 home victory over Portsmouth.
Referee Lee Probert pointed to the spot after England goalkeeper David James had clattered into Blues midfielder Sebastian Larsson.
Up stepped McFadden to drill the ball past the 39-year-old who had earlier denied the home side with fine saves from Larsson and veteran striker Kevin Phillips.